Ethan Hunt får den umulige opgave at stoppe den afhoppede agent Sean Ambrose fra at sprede dræbervirusen Chimera over Australien. Som hjælper får Ethan Seans eks-kæreste, mestertyven Nyah Hall. Selvfølgelig forelsker Ethan og Nyah sig i hinanden, og missionen bliver endnu mere umulig, da Sean tager Nyah til fange.
With computer genius Luther Stickell at his side and a beautiful thief on his mind, agent Ethan Hunt races across Australia and Spain to stop a former IMF agent from unleashing a genetically engineered biological weapon called Chimera. This mission, should Hunt choose to accept it, plunges him into the center of an international crisis of terrifying magnitude.
WWII American Army Medic Desmond T. Doss, who served during the Battle of Okinawa, refuses to kill people and becomes the first Conscientious Objector in American history to win the Congressional Medal of Honor.